DISITAMAB VEDOTIN COMBINED WITH PYROTINIB AS SALVAGE TREATMENT IN HER-2-AMPLIFIED TREATMENT REFRACTORY METASTATIC COLORECTAL CANCER: A CASE REPORT

Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report

BackgroundHuman epidermal growth factor receptor 2 (HER-2) amplification has been identified in approximately 3% of patients with metastatic colorectal cancer (mCRC).Owing to the lack of established anti-ERBB2 therapeutic approaches, mCRC patients with Her-2 amplification rarely receive targeted treatments.Moreover, conventional chemotherapy regime

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The Challenge of Sustainability: Turning Science into Art

This paper addresses the critical question of how to turn climate concern into climate action as we move forward towards the 1.5-degree Celsius global warming target adopted by COP 26 Missouri Star Souvenirs in 2021 and reaffirmed by COP 27 in 2022.It argues that it has taken scientists more than a Century to accept, first: that climate change is r

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Dengue virus in Aedes aegypti and Aedes albopictus in urban areas in the state of Rio Grande do Norte, Brazil: Importance of virological and entomological surveillance.

Vector control remains the sole effective method to prevent dengue virus (DENV) transmission, although a vaccine for dengue has recently become available and testing of its efficacy and coverage is being performed in Food Service multiple places.Entomological surveillance is a key factor in alerting authorities to possible outbreaks, but until now

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